8ZC5

SARS-CoV-2 Omicron BA.4 spike trimer (6P) in complex with D1F6 Fab, focused refinement of RBD region

8ZC5 の概要

• エントリーDOI: 10.2210/pdb8zc5/pdb
• EMDBエントリー: 39923
• 分子名称: Spike protein S1, Light chain of D1F6 Fab, Heavy chain of D1F6 Fab, ... (4 entities in total)
• 機能のキーワード: spike protein, antibody fab fragment, complex, viral protein/immune system, viral protein-immune system complex
• 由来する生物種: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 96297.58

構造登録者

Liu, B.,Gao, X.,Li, Z.,Chen, Q.,He, J.,Xiong, X. (登録日: 2024-04-28, 公開日: 2024-05-15, 最終更新日: 2024-06-12)

• 主引用文献: Liu, B.,Niu, X.,Deng, Y.,Zhang, Z.,Wang, Y.,Gao, X.,Liang, H.,Li, Z.,Wang, Q.,Cheng, Y.,Chen, Q.,Huang, S.,Pan, Y.,Su, M.,Lin, X.,Niu, C.,Chen, Y.,Yang, W.,Zhang, Y.,Yan, Q.,He, J.,Zhao, J.,Chen, L.,Xiong, X.; An unconventional VH1-2 antibody tolerates escape mutations and shows an antigenic hotspot on SARS-CoV-2 spike.; Cell Rep, 43:114265-114265, 2024; PubMed: 38805396; DOI: 10.1016/j.celrep.2024.114265

実験手法

ELECTRON MICROSCOPY (3.91 Å)