8Z9B

Low molecular weight antigen MTB12

8Z9B の概要

• エントリーDOI: 10.2210/pdb8z9b/pdb
• 分子名称: Low molecular weight antigen MTB12 (1 entity in total)
• 機能のキーワード: antigen, secretory protein, immune system
• 由来する生物種: Mycobacterium tuberculosis CDC1551
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27710.92

構造登録者

Park, H.H.,Han, J.H. (登録日: 2024-04-23, 公開日: 2024-05-29, 最終更新日: 2024-07-10)

主引用文献

Han, J.H.,Kim, D.Y.,Lee, S.Y.,Park, H.H.
Novel structure of secreted small molecular weight antigen Mtb12 from Mycobacterium tuberculosis.
Biochem.Biophys.Res.Commun., 717:150040-150040, 2024

PubMed Abstract: Mtb12, a small protein secreted by Mycobacterium tuberculosis, is known to elicit immune responses in individuals infected with the pathogen. It serves as an antigen recognized by the host's immune system. Due to its immunogenic properties and pivotal role in tuberculosis (TB) pathogenesis, Mtb12 is considered a promising candidate for TB diagnosis and vaccine development. However, the structural and functional properties of Mtb12 are largely unexplored, representing a significant gap in our understanding of M. tuberculosis biology. In this study, we present the first structure of Mtb12, which features a unique tertiary configuration consisting of four beta strands and four alpha helices. Structural analysis reveals that Mtb12 has a surface adorned with a negatively charged pocket adjacent to a central cavity. The features of these structural elements and their potential effects on the function of Mtb12 warrant further exploration. These findings offer valuable insights for vaccine design and the development of diagnostic tools.

PubMed: 38718566
DOI: 10.1016/j.bbrc.2024.150040

実験手法

X-RAY DIFFRACTION (2.68 Å)