8Z1L

Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom.

This is a non-PDB format compatible entry.

Summary for 8Z1L

• Entry DOI: 10.2210/pdb8z1l/pdb
• Related: 8HFE
• EMDB information: 34718 39729
• Descriptor: Sodium-dependent noradrenaline transporter, CHLORIDE ION, (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (3 entities in total)
• Functional Keywords: norepinephrine transporter, net, slc6a2, norepinephrine, atomoxetine, neurotransmitter, desipramine, antidepressant., transport protein, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 69677.35

Authors

Tan, J.,Xiao, Y.,Kong, F.,Lei, J.,Yuan, Y.,Yan, C. (deposition date: 2024-04-11, release date: 2024-07-31, Last modification date: 2024-09-04)

• Primary citation: Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C.; Molecular basis of human noradrenaline transporter reuptake and inhibition.; Nature, 632:921-929, 2024; PubMed: 39048818; DOI: 10.1038/s41586-024-07719-z

Experimental method

ELECTRON MICROSCOPY (3.4 Å)