8Z1L
Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant atomoxetine in an outward-open state at resolution of 3.4 angstrom.
This is a non-PDB format compatible entry.
Summary for 8Z1L
Entry DOI | 10.2210/pdb8z1l/pdb |
Related | 8HFE |
EMDB information | 34718 39729 |
Descriptor | Sodium-dependent noradrenaline transporter, CHLORIDE ION, (3R)-N-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (3 entities in total) |
Functional Keywords | norepinephrine transporter, net, slc6a2, norepinephrine, atomoxetine, neurotransmitter, desipramine, antidepressant., transport protein, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 69677.35 |
Authors | |
Primary citation | Tan, J.,Xiao, Y.,Kong, F.,Zhang, X.,Xu, H.,Zhu, A.,Liu, Y.,Lei, J.,Tian, B.,Yuan, Y.,Yan, C. Molecular basis of human noradrenaline transporter reuptake and inhibition. Nature, 632:921-929, 2024 Cited by PubMed: 39048818DOI: 10.1038/s41586-024-07719-z PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)