8YXA

Crystal structure of the HSA complex with cefazolin and myristate

Summary for 8YXA

• Entry DOI: 10.2210/pdb8yxa/pdb
• Related: 8YXB
• Descriptor: Serum albumin, (6~{R},7~{R})-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxidanylidene-7-[2-(1,2,3,4-tetrazol-1-yl)ethanoylamino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, MYRISTIC ACID (3 entities in total)
• Functional Keywords: human serum albumin, antibiotics complex, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 135193.31

Authors

Kawai, A. (deposition date: 2024-04-02, release date: 2024-08-07, Last modification date: 2024-09-04)

• Primary citation: Kawai, A.,Yamasaki, K.,Otagiri, M.,Doi, Y.; Interaction of Cephalosporins with Human Serum Albumin: A Structural Study.; J.Med.Chem., 67:14175-14183, 2024; PubMed: 39083648; DOI: 10.1021/acs.jmedchem.4c00983

Experimental method

X-RAY DIFFRACTION (2.5 Å)