8YW5

Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex

Summary for 8YW5

Entry DOI	10.2210/pdb8yw5/pdb
EMDB information	39623
Descriptor	Retatrutide, Glucagon receptor, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... (6 entities in total)
Functional Keywords	g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, retatrutide, structural protein
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	156902.22
Authors	Li, W.Z.,Zhou, Q.T.,Cong, Z.T.,Yuan, Q.N.,Li, W.X.,Zhao, F.H.,Xu, H.E.,Zhao, L.H.,Yang, D.H.,Wang, M.W. (deposition date: 2024-03-29, release date: 2024-08-07)
Primary citation	Li, W.,Zhou, Q.,Cong, Z.,Yuan, Q.,Li, W.,Zhao, F.,Xu, H.E.,Zhao, L.H.,Yang, D.,Wang, M.W. Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide. Cell Discov, 10:77-77, 2024 Cited by PubMed: 39019866 DOI: 10.1038/s41421-024-00700-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.84 Å)

Structure validation