8YUU

Cryo-EM structure of the histamine-bound H3R-Gi complex

8YUU の概要

• エントリーDOI: 10.2210/pdb8yuu/pdb
• EMDBエントリー: 39583
• 分子名称: Histamine H3 receptor, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (7 entities in total)
• 機能のキーワード: gpcr, h3r, histamine receptor, membrane protein/immune system, membrane protein-immune system complex
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 167607.35

構造登録者

Shen, Q.,Tang, X.,Wen, X.,Cheng, S.,Xiao, P.,Zang, S.,Shen, D.,Jiang, L.,Zheng, Y.,Zhang, H.,Xu, H.,Mao, C.,Zhang, M.,Hu, W.,Sun, J.,Chen, Z.,Zhang, Y. (登録日: 2024-03-27, 公開日: 2024-06-05, 最終更新日: 2024-07-03)

• 主引用文献: Shen, Q.,Tang, X.,Wen, X.,Cheng, S.,Xiao, P.,Zang, S.K.,Shen, D.D.,Jiang, L.,Zheng, Y.,Zhang, H.,Xu, H.,Mao, C.,Zhang, M.,Hu, W.,Sun, J.P.,Zhang, Y.,Chen, Z.; Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.; Adv Sci, 11:e2310120-e2310120, 2024; PubMed: 38647423; DOI: 10.1002/advs.202310120

実験手法

ELECTRON MICROSCOPY (2.7 Å)