8YTK

Crystal structure of human prolyl-tRNA synthetase in complex with inhibitor

Summary for 8YTK

• Entry DOI: 10.2210/pdb8ytk/pdb
• Descriptor: Bifunctional glutamate/proline--tRNA ligase, (2~{S})-~{N}-[3-(4-azanylquinazolin-7-yl)phenyl]sulfonylpyrrolidine-2-carboxamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: prolyl-trna synthetase, inhibitor, complex, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 120169.18

Authors

Luo, Z.,Zhou, H. (deposition date: 2024-03-26, release date: 2025-04-02)

• Primary citation: Luo, Z.,Qiu, H.,Tan, Q.,Chen, B.,Xu, J.,Gu, Q.,Zhou, H.; Development of Potent Inhibitors Against Bacterial Prolyl-tRNA Synthetase Using Fluorine Scanning; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.553 Å)