8YTE

Crystal Structure of TrkA D5 domain in complex with macrocyclic peptide

Summary for 8YTE

Entry DOI	10.2210/pdb8yte/pdb
Descriptor	High affinity nerve growth factor receptor, Macrocyclic Peptide, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	transferase, cyclic peptide
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	26391.68
Authors	Yamada, T.,Mihara, K.,Ueda, T.,Yamauchi, D.,Shimizu, M.,Ando, A.,Mayumi, K.,Nakata, Z.,Mikamiyama, H. (deposition date: 2024-03-25, release date: 2024-07-10)
Primary citation	Yamada, T.,Mihara, K.,Ueda, T.,Yamauchi, D.,Shimizu, M.,Ando, A.,Mayumi, K.,Nakata, Z.,Mikamiyama, H. Discovery and Hit to Lead Optimization of Macrocyclic Peptides as Novel Tropomyosin Receptor Kinase A Antagonists J.Med.Chem., 2024 Cited by DOI: 10.1021/acs.jmedchem.4c00715 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation