8YPK

mouse proteasome 20S subunit in complex with compound 1

This is a non-PDB format compatible entry.

Summary for 8YPK

• Entry DOI: 10.2210/pdb8ypk/pdb
• EMDB information: 39482
• Descriptor: Proteasome subunit beta type-6, Proteasome subunit alpha type-5, Proteasome subunit alpha type-4, ... (15 entities in total)
• Functional Keywords: inhibitor, complex, proteasome, hydrolase
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 28
• Total formula weight: 734353.68

Authors

Kashima, A.,Arai, Y. (deposition date: 2024-03-17, release date: 2024-07-31)

• Primary citation: Arai, Y.,Shitama, H.,Yamagishi, M.,Ono, S.,Kashima, A.,Hiraizumi, M.,Tsuda, N.,Katayama, K.,Tanaka, K.,Koda, Y.,Kato, S.,Sakata, K.,Nureki, O.,Miyazaki, H.; Optimization of alpha-amido boronic acids via cryo-electron microscopy analysis: Discovery of a novel highly selective immunoproteasome subunit LMP7 ( beta 5i)/LMP2 ( beta 1i) dual inhibitor.; Bioorg.Med.Chem., 109:117790-117790, 2024; PubMed: 38906067; DOI: 10.1016/j.bmc.2024.117790

Experimental method

ELECTRON MICROSCOPY (2.7 Å)