8YN2

Cryo-EM structure of histamine H1 receptor in complex with histamine and miniGq

8YN2 の概要

• エントリーDOI: 10.2210/pdb8yn2/pdb
• EMDBエントリー: 39412
• 分子名称: Engineered guanine nucleotide-binding protein G(q) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• 機能のキーワード: gpcr, signaling protein
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 186918.89

構造登録者

Zhang, X.,Liu, G.,Li, X.,Gong, W. (登録日: 2024-03-10, 公開日: 2024-10-09)

• 主引用文献: Zhang, X.,Liu, G.,Zhong, Y.N.,Zhang, R.,Yang, C.C.,Niu, C.,Pu, X.,Sun, J.,Zhang, T.,Yang, L.,Zhang, C.,Li, X.,Shen, X.,Xiao, P.,Sun, J.P.,Gong, W.; Structural basis of ligand recognition and activation of the histamine receptor family; Nat Commun, 15:8296-, 2024; DOI: 10.1038/s41467-024-52585-y

実験手法

ELECTRON MICROSCOPY (2.66 Å)