8YMH

BRD4-BD1 in complex with 5-methyl-2-{[(2R)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}-7-(1-methylpyrazol-3-yl)furo[3,2-c]pyridin-4-one

This is a non-PDB format compatible entry.

Summary for 8YMH

• Entry DOI: 10.2210/pdb8ymh/pdb
• Descriptor: Bromodomain-containing protein 4, 5-methyl-2-{[(2R)-2-methyl-4-methylsulfonyl-piperazin-1-yl]methyl}-7-(1-methylpyrazol-3-yl)furo[3,2-c]pyridin-4-one, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: brd4, epigenetic, signaling protein-inhibitor complex, signaling protein/inhibitor, signaling protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15700.07

Authors

Sasaki, C.,Miyaguchi, I.,Hagihara, S.,Ishizawa, K.,Endo, J. (deposition date: 2024-03-09, release date: 2025-03-12)

• Primary citation: Hagihara, S.,Ishizawa, K.,Kikuchi, M.,Kawano, Y.,Nishidate, A.,Matsumoto, F.,Hashimoto, N.,Sasaki, C.,Miyaguchi, I.,Okada, O.,Akashi, T.,Nakayama, S.,Ogasawara, Y.,Endo, J.; Discovery of a potent, orally available furopyridine derivative as a novel selective BET BD1 Inhibitor (Part 1).; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.04 Å)