8YLS

Structure of SARS-CoV-2 Mpro in complex with its degrader

This is a non-PDB format compatible entry.

Summary for 8YLS

• Entry DOI: 10.2210/pdb8yls/pdb
• Descriptor: 3C-like proteinase nsp5, (4-methoxyphenyl)methyl ~{N}-[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]pentan-2-yl]carbamate (3 entities in total)
• Functional Keywords: severe acute respiratory syndrome coronavirus 2, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 34259.04

Authors

Feng, Y.,Li, W.,Cheng, S.H.,Li, X.B. (deposition date: 2024-03-06, release date: 2024-09-04)

• Primary citation: Cheng, S.H.,Feng, Y.,Li, W.,Li, X.B.; The Main Protease Degraders: Potent Broad-Spectrum Agents for Anti-Coronavirus Agents; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)