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8YBC

Crystal structure of coiled coil domain of Golm1 (Golgi membrane protein 1)

8YBC の概要
エントリーDOI10.2210/pdb8ybc/pdb
分子名称Golgi membrane protein 1 (2 entities in total)
機能のキーワードtetramer, coiled coil, alpha-helix, oncoprotein
由来する生物種Homo sapiens (human)
タンパク質・核酸の鎖数4
化学式量合計32572.75
構造登録者
Xie, X.,Bai, W.F.,Shi, N. (登録日: 2024-02-12, 公開日: 2025-02-12)
主引用文献Bai, W.,Li, B.,Wu, P.,Li, X.,Huang, X.,Shi, N.,Yang, C.,Hu, F.,Xie, X.
The first structure of human Golm1 coiled coil domain reveals an unexpected tetramer and highlights its structural diversity.
Int.J.Biol.Macromol., 275:133624-133624, 2024
Cited by
PubMed Abstract: Golgi membrane protein 1 (Golm1), a transmembrane protein with diverse subcellular localizations, has garnered significant attention in recent years due to its strong association with the development and progression of liver diseases and numerous cancers. Interestingly, although Golm1 is a membrane protein, the C-terminal of Golm1, which contains a coiled coil domain and a flexible acid region, can also be detected in the plasma of patients with various liver diseases. Notably, the coiled coil domain of serum Golm1 is postulated to play a pivotal role in physiological and pathological functions. However, little is currently known about the structure of this coiled coil domain and the full-length protein, which may limit our understanding of Golm1. Therefore, this study aims to address this gap in knowledge and reports the first crystal structure of the coiled coil domain of Golm1 at a resolution of 2.28 Å. Meanwhile, we have also confirmed that the Golm1 coiled coil domain in solution can form tetramer. Our results reveal that Golm1 can form a novel tetrameric structure that differs from the previous reported dimeric structure Golm1 could assemble, which may provide novel insights into the diversity of physiological functions and pathological roles.
PubMed: 38964685
DOI: 10.1016/j.ijbiomac.2024.133624
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.28 Å)
構造検証レポート
Validation report summary of 8ybc
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-16に公開中

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