8Y89

Structure of HCoV-HKU1C spike in the functionally anchored-3up conformation with 2TMPRSS2

Summary for 8Y89

• Entry DOI: 10.2210/pdb8y89/pdb
• EMDB information: 39038
• Descriptor: Spike glycoprotein, Transmembrane protease serine 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: hku1c, spike, tmprss2, viral protein
• Biological source: Human coronavirus HKU1 (Human coronavirus HKU1 (isolate N5)); More
• Total number of polymer chains: 5
• Total formula weight: 513000.87

Authors

Lu, Y.C.,Wang, H.F.,Zhang, X.,Liu, X.C.,Sun, L.,Yang, H.T. (deposition date: 2024-02-06, release date: 2024-07-17, Last modification date: 2024-08-28)

• Primary citation: Wang, H.,Liu, X.,Zhang, X.,Zhao, Z.,Lu, Y.,Pu, D.,Zhang, Z.,Chen, J.,Wang, Y.,Li, M.,Dong, X.,Duan, Y.,He, Y.,Mao, Q.,Guo, H.,Sun, H.,Zhou, Y.,Yang, Q.,Gao, Y.,Yang, X.,Cao, H.,Guddat, L.,Sun, L.,Rao, Z.,Yang, H.; TMPRSS2 and glycan receptors synergistically facilitate coronavirus entry.; Cell, 187:4261-, 2024; PubMed: 38964329; DOI: 10.1016/j.cell.2024.06.016

Experimental method

ELECTRON MICROSCOPY (3.32 Å)