8Y6U
Cryo-EM structure of E.coli transcription initiation complex with transcription factor GcvA
This is a non-PDB format compatible entry.
Summary for 8Y6U
| Entry DOI | 10.2210/pdb8y6u/pdb |
| EMDB information | 39001 |
| Descriptor | Glycine cleavage system transcriptional activator, Non-template promoter DNA, Template promoter DNA, ... (8 entities in total) |
| Functional Keywords | rna polymerase, transcription-dna complex, transcription/dna |
| Biological source | Escherichia coli K-12 More |
| Total number of polymer chains | 11 |
| Total formula weight | 622259.06 |
| Authors | |
| Primary citation | Ichijo, R.,Kawai, G. NMR analysis of a loop-bulge structure of UUCGA pentaloop. Biochem.Biophys.Res.Commun., 691:149327-149327, 2024 Cited by PubMed Abstract: Although structures of many RNA loops, such as GNRA and UNCG tetraloops, were well known, it is still possible to find more RNA structures. In the present study, solution structure of an RNA fragment having UUCGA pentaloop was analyzed by NMR spectroscopy. It was found that the UUCG tetraloop is formed and the adenosine residue at the 3' side of the tetraloop is bulged out. The characteristic motif of the loop-bulge structure has also been found in other RNAs including CUUGU and CUGGC pentaloops. Along with the recently found T-hairpin structure with a UUUGAUU loop, in which UUUGA pentaloop and UU bulge are formed, the loop-bulge structures can be categorized as an RNA motif and it may be called as the integrated structure loop, I-loop. PubMed: 38039839DOI: 10.1016/j.bbrc.2023.149327 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.97 Å) |
Structure validation
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