8Y58

Crystal structure of TRIM21 PRYSPRY (D355A) in complex with acepromazine.

Summary for 8Y58

• Entry DOI: 10.2210/pdb8y58/pdb
• Related: 8Y59 8Y5B
• Descriptor: E3 ubiquitin-protein ligase TRIM21, 1-[10-(3-DIMETHYLAMINO-PROPYL)-10H-PHENOTHIAZIN-2-YL]-ETHANONE, FORMIC ACID, ... (4 entities in total)
• Functional Keywords: trim21, pryspry, acepromazine, ligase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 22061.76

Authors

Lu, P.,Cheng, Y.,Xue, L.,Ren, X.,Huang, N.,Han, T. (deposition date: 2024-01-31, release date: 2024-10-09)

• Primary citation: Lu, P.,Cheng, Y.,Xue, L.,Ren, X.,Chen, C.,Li, J.,Wu, Q.,Sun, S.,Hou, J.,Jia, W.,Li, C.,Qi, X.,Huang, N.,Han, T.; Selective degradation of multimeric proteins via chemically induced proximity to TRIM21.; To be published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)