8Y3Y

The Cryo-EM structure of anti-phage defense associated DSR2 tetramer bound with two DSAD1 inhibitors (opposite side)

Summary for 8Y3Y

Entry DOI	10.2210/pdb8y3y/pdb
EMDB information	38907
Descriptor	SIR2-like domain-containing protein, DSR anti-defence 1 (2 entities in total)
Functional Keywords	nadase, anti-phage defense, complex, immune evasion, immunosuppressant
Biological source	Bacillus subtilis More
Total number of polymer chains	6
Total formula weight	502289.02
Authors	Wang, R.W.,Xu, Q.,Wu, Z.X.,Li, J.L.,Shi, Z.B.,Li, F.X. (deposition date: 2024-01-29, release date: 2024-09-11)
Primary citation	Wang, R.,Xu, Q.,Wu, Z.,Li, J.,Guo, H.,Liao, T.,Shi, Y.,Yuan, L.,Gao, H.,Yang, R.,Shi, Z.,Li, F. The structural basis of the activation and inhibition of DSR2 NADase by phage proteins. Nat Commun, 15:6185-6185, 2024 Cited by PubMed: 39039073 DOI: 10.1038/s41467-024-50410-0 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.33 Å)

Structure validation