8Y2G

Cryo-EM structure of human dopamine transporter in complex with methylphenidate

This is a non-PDB format compatible entry.

Summary for 8Y2G

• Entry DOI: 10.2210/pdb8y2g/pdb
• EMDB information: 38854
• Descriptor: Sodium-dependent dopamine transporter, methyl (2~{R})-2-phenyl-2-[(2~{R})-piperidin-2-yl]ethanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: human dopamine transporter in complex with methylphenidate, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 63208.58

Authors

Zhao, Y.,Li, Y. (deposition date: 2024-01-25, release date: 2024-08-14, Last modification date: 2024-08-28)

• Primary citation: Li, Y.,Wang, X.,Meng, Y.,Hu, T.,Zhao, J.,Li, R.,Bai, Q.,Yuan, P.,Han, J.,Hao, K.,Wei, Y.,Qiu, Y.,Li, N.,Zhao, Y.; Dopamine reuptake and inhibitory mechanisms in human dopamine transporter.; Nature, 632:686-694, 2024; PubMed: 39112701; DOI: 10.1038/s41586-024-07796-0

Experimental method

ELECTRON MICROSCOPY (2.83 Å)