8Y22

FGFR1 kinase domain with a covalent inhibitor 9g

This is a non-PDB format compatible entry.

Summary for 8Y22

• Entry DOI: 10.2210/pdb8y22/pdb
• Descriptor: Fibroblast growth factor receptor 1, ~{N}-[4-[[4-azanyl-3-(7-methoxy-5-methyl-1-benzothiophen-2-yl)pyrazolo[3,4-d]pyrimidin-1-yl]methyl]phenyl]propanamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: fibroblast growth factor receptor 1, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 71838.27

Authors

Chen, X.J.,Chen, Y.H. (deposition date: 2024-01-25, release date: 2024-06-26)

• Primary citation: Deng, W.,Chen, X.,Liang, H.,Song, X.,Xiang, S.,Guo, J.,Tu, Z.,Zhou, Y.,Chen, Y.,Lu, X.; Design, synthesis and biological evaluation of 5-amino-1H-pyrazole-4-carboxamide derivatives as pan-FGFR covalent inhibitors.; Eur.J.Med.Chem., 275:116558-116558, 2024; PubMed: 38870833; DOI: 10.1016/j.ejmech.2024.116558

Experimental method

X-RAY DIFFRACTION (2.792 Å)