8XSZ

Cryo-EM structure of the human 80S ribosome with Tigecycline, E-tRNA and P-tRNA

This is a non-PDB format compatible entry.

Summary for 8XSZ

• Entry DOI: 10.2210/pdb8xsz/pdb
• EMDB information: 38631
• Descriptor: 28S rRNA, 60S ribosomal protein L7a, 60S ribosomal protein L9, ... (88 entities in total)
• Functional Keywords: ribosome, tigecycline, antibiotic, ccdc124
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 86
• Total formula weight: 3982703.42

Authors

Li, X.,Wang, M.,Cheng, J. (deposition date: 2024-01-10, release date: 2024-07-10)

• Primary citation: Li, X.,Wang, M.,Denk, T.,Buschauer, R.,Li, Y.,Beckmann, R.,Cheng, J.; Structural basis for differential inhibition of eukaryotic ribosomes by tigecycline.; Nat Commun, 15:5481-5481, 2024; PubMed: 38942792; DOI: 10.1038/s41467-024-49797-7

Experimental method

ELECTRON MICROSCOPY (3.2 Å)