8XQN

Structure of human class T GPCR TAS2R14-DNGi complex with Aristolochic acid A.

Summary for 8XQN

• Entry DOI: 10.2210/pdb8xqn/pdb
• EMDB information: 38582
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: gpcr, dngi, goq, tas2r14, bitter receptor, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 232280.88

Authors

Hu, X.L.,Wu, L.J.,Hua, T.,Liu, Z.J. (deposition date: 2024-01-05, release date: 2024-07-10)

• Primary citation: Hu, X.,Ao, W.,Gao, M.,Wu, L.,Pei, Y.,Liu, S.,Wu, Y.,Zhao, F.,Sun, Q.,Liu, J.,Jiang, L.,Wang, X.,Li, Y.,Tan, Q.,Cheng, J.,Yang, F.,Yang, C.,Sun, J.,Hua, T.,Liu, Z.J.; Bitter taste TAS2R14 activation by intracellular tastants and cholesterol.; Nature, 2024; PubMed: 38776963; DOI: 10.1038/s41586-024-07569-9

Experimental method

ELECTRON MICROSCOPY (3.05 Å)