8XFV

Crystal structure of human Golgi resident glutaminyl cyclase in complex with (Z)-3-((1H-benzo[d]imidazol-5-yl)methylene)-4-(piperidin-4-yloxy)indolin-2-one

This is a non-PDB format compatible entry.

Summary for 8XFV

• Entry DOI: 10.2210/pdb8xfv/pdb
• Descriptor: Glutaminyl-peptide cyclotransferase-like protein, ZINC ION, 3-(1~{H}-benzimidazol-5-ylmethylidene)-4-piperidin-4-yloxy-1~{H}-indol-2-one, ... (4 entities in total)
• Functional Keywords: inhibitor, complex, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 11
• Total formula weight: 389567.26

Authors

Li, G.-B.,Wang, X.-Y. (deposition date: 2023-12-14, release date: 2024-06-12, Last modification date: 2024-06-26)

• Primary citation: Mou, J.,Ning, X.L.,Wang, X.Y.,Hou, S.Y.,Meng, F.B.,Zhou, C.,Wu, J.W.,Li, C.,Jia, T.,Wu, X.,Wu, Y.,Chen, Y.,Li, G.B.; X-ray Structure-Guided Discovery of a Potent Benzimidazole Glutaminyl Cyclase Inhibitor That Shows Activity in a Parkinson's Disease Mouse Model.; J.Med.Chem., 67:8730-8756, 2024; PubMed: 38817193; DOI: 10.1021/acs.jmedchem.4c00049

Experimental method

X-RAY DIFFRACTION (3.13 Å)