8XB2

Structure of radafaxine-bound state of the human Norepinephrine Transporter

8XB2 の概要

• エントリーDOI: 10.2210/pdb8xb2/pdb
• EMDBエントリー: 38208
• 分子名称: GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol (3 entities in total)
• 機能のキーワード: antidepressant, bupropion, transport protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 139173.97

構造登録者

Wu, J.X.,Ji, W.M. (登録日: 2023-12-05, 公開日: 2024-07-10, 最終更新日: 2024-08-28)

• 主引用文献: Ji, W.,Miao, A.,Liang, K.,Liu, J.,Qi, Y.,Zhou, Y.,Duan, X.,Sun, J.,Lai, L.,Wu, J.X.; Substrate binding and inhibition mechanism of norepinephrine transporter.; Nature, 2024; PubMed: 39143211; DOI: 10.1038/s41586-024-07810-5

実験手法

ELECTRON MICROSCOPY (3.04 Å)