8WX7
Crystal structure of SHP2 in complex with JAB-3186
Summary for 8WX7
Entry DOI | 10.2210/pdb8wx7/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 11, 1,2-ETHANEDIOL, (5~{S})-1'-[6-azanyl-5-(2-azanyl-3-chloranyl-pyridin-4-yl)sulfanyl-pyrazin-2-yl]spiro[5,7-dihydrocyclopenta[b]pyridine-6,4'-piperidine]-5-amine, ... (6 entities in total) |
Functional Keywords | phosphatase cancer, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 123191.41 |
Authors | |
Primary citation | Ma, C.,Kang, D.,Gao, P.,Zhang, W.,Wu, X.,Xu, Z.,Han, H.,Zhang, L.,Cai, Y.,Wang, Y.,Wang, Y.,Long, W. Discovery of JAB-3312, a Potent SHP2 Allosteric Inhibitor for Cancer Treatment. J.Med.Chem., 67:13534-13549, 2024 Cited by PubMed: 39110625DOI: 10.1021/acs.jmedchem.4c00360 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.02 Å) |
Structure validation
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