8WWB

The sigma-1 receptor from Xenopus laevis in complex with dehydroepiandrosterone sulfate by soaking (I432 form)

Summary for 8WWB

• Entry DOI: 10.2210/pdb8wwb/pdb
• Related: 8WUE
• Descriptor: Sigma non-opioid intracellular receptor 1, 17-oxoandrost-5-en-3beta-yl hydrogen sulfate (3 entities in total)
• Functional Keywords: sigma receptor, s1r, endogenous ligand, neurosteroid, dheas, membrane protein
• Biological source: Xenopus laevis (African clawed frog)
• Total number of polymer chains: 1
• Total formula weight: 26088.81

Authors

Fu, C.,Sun, Z.,Zhou, X. (deposition date: 2023-10-25, release date: 2024-07-17)

• Primary citation: Fu, C.,Xiao, Y.,Zhou, X.,Sun, Z.; Insight into binding of endogenous neurosteroid ligands to the sigma-1 receptor.; Nat Commun, 15:5619-5619, 2024; PubMed: 38965213; DOI: 10.1038/s41467-024-49894-7

Experimental method

X-RAY DIFFRACTION (2.503 Å)