8WSU

Crystal structure of SFTSV Gc and antibody

Summary for 8WSU

• Entry DOI: 10.2210/pdb8wsu/pdb
• Descriptor: Glycoprotein C, Ab-H, Ab-L (3 entities in total)
• Functional Keywords: virus, antibody, viral protein/immune system, viral protein-immune system complex
• Biological source: SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus); More
• Total number of polymer chains: 6
• Total formula weight: 188636.17

Authors

Chang, Z.,Gao, F.,Wu, Y. (deposition date: 2023-10-17, release date: 2024-06-12)

• Primary citation: Chang, Z.,Gao, D.,Liao, L.,Sun, J.,Zhang, G.,Zhang, X.,Wang, F.,Li, C.,Oladejo, B.O.,Li, S.,Chai, Y.,Hu, Y.,Lu, X.,Xiao, H.,Qi, J.,Chen, Z.,Gao, F.,Wu, Y.; Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model.; Proc.Natl.Acad.Sci.USA, 121:e2400163121-e2400163121, 2024; PubMed: 38830098; DOI: 10.1073/pnas.2400163121

Experimental method

X-RAY DIFFRACTION (3.3 Å)