8WQH

cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2)

Summary for 8WQH

Entry DOI	10.2210/pdb8wqh/pdb
EMDB information	37745
Descriptor	Cullin-2, E3 ubiquitin-protein ligase RBX1, N-terminally processed, Elongin-C, ... (7 entities in total)
Functional Keywords	e3 ubiquitin ligase, pro/c-degron, ligase
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	392155.43
Authors	Chen, X.,Zhang, K.,Xu, C. (deposition date: 2023-10-11, release date: 2024-04-03, Last modification date: 2024-05-08)
Primary citation	Chen, X.,Raiff, A.,Li, S.,Guo, Q.,Zhang, J.,Zhou, H.,Timms, R.T.,Yao, X.,Elledge, S.J.,Koren, I.,Zhang, K.,Xu, C. Mechanism of Psi-Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase. Nat Commun, 15:3558-3558, 2024 Cited by PubMed: 38670995 DOI: 10.1038/s41467-024-47890-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.44 Å)

Structure validation