8WM9

Fzd4/DEP complex

Summary for 8WM9

Entry DOI	10.2210/pdb8wm9/pdb
EMDB information	37646
Descriptor	Frizzled-4, Segment polarity protein dishevelled homolog DVL-2, CHOLESTEROL HEMISUCCINATE (3 entities in total)
Functional Keywords	gpcr complex, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	203999.06
Authors	He, Y.,Qian, Y. (deposition date: 2023-10-03, release date: 2024-09-11)
Primary citation	Qian, Y.,Ma, Z.,Xu, Z.,Duan, Y.,Xiong, Y.,Xia, R.,Zhu, X.,Zhang, Z.,Tian, X.,Yin, H.,Liu, J.,Song, J.,Lu, Y.,Zhang, A.,Guo, C.,Jin, L.,Kim, W.J.,Ke, J.,Xu, F.,Huang, Z.,He, Y. Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation. Nat Commun, 15:7644-7644, 2024 Cited by PubMed: 39223191 DOI: 10.1038/s41467-024-52174-z PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.53 Å)

Structure validation