8WKZ
Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31
Summary for 8WKZ
Entry DOI | 10.2210/pdb8wkz/pdb |
Descriptor | Melanocortin receptor 4, [N-(3-{bis[2-(pyridin-2-yl-kappaN)ethyl]amino-kappaN}propyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide](azido)(hydroxy)copper, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | ca++ cofactor, gpcr, pgs fusion, membrane protein, lcp |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 62844.16 |
Authors | Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.,Dahir, N.S.,Wu, Y.,Yao, D.,Han, G.W.,Wu, L.,Poorten, O.V.,Lamouroux, A.,Mannes, M.,Tourwe, D.,Zhao, S.,Stevens, R.C.,Cone, R.D.,Ballet, S. (deposition date: 2023-09-28, release date: 2024-08-07) |
Primary citation | Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.C.,Wu, Y.,Yao, D.,Han, G.W.,Dahir, N.S.,Wu, L.,Van der Poorten, O.,Lamouroux, A.,Mannes, M.,Zhao, S.,Tourwe, D.,Stevens, R.C.,Cone, R.D.,Ballet, S. Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design. J.Med.Chem., 67:2690-2711, 2024 Cited by PubMed: 38345933DOI: 10.1021/acs.jmedchem.3c01822 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
Download full validation report