8WKZ

Crystal structure of the Melanocortin-4 Receptor (MC4R) in complex with S31

8WKZ の概要

• エントリーDOI: 10.2210/pdb8wkz/pdb
• 分子名称: Melanocortin receptor 4, [N-(3-{bis[2-(pyridin-2-yl-kappaN)ethyl]amino-kappaN}propyl)-5-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide](azido)(hydroxy)copper, CALCIUM ION, ... (5 entities in total)
• 機能のキーワード: ca++ cofactor, gpcr, pgs fusion, membrane protein, lcp
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62844.16

構造登録者

Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.,Dahir, N.S.,Wu, Y.,Yao, D.,Han, G.W.,Wu, L.,Poorten, O.V.,Lamouroux, A.,Mannes, M.,Tourwe, D.,Zhao, S.,Stevens, R.C.,Cone, R.D.,Ballet, S. (登録日: 2023-09-28, 公開日: 2024-08-07)

• 主引用文献: Gimenez, L.E.,Martin, C.,Yu, J.,Hollanders, C.,Hernandez, C.C.,Wu, Y.,Yao, D.,Han, G.W.,Dahir, N.S.,Wu, L.,Van der Poorten, O.,Lamouroux, A.,Mannes, M.,Zhao, S.,Tourwe, D.,Stevens, R.C.,Cone, R.D.,Ballet, S.; Novel Cocrystal Structures of Peptide Antagonists Bound to the Human Melanocortin Receptor 4 Unveil Unexplored Grounds for Structure-Based Drug Design.; J.Med.Chem., 67:2690-2711, 2024; PubMed: 38345933; DOI: 10.1021/acs.jmedchem.3c01822

実験手法

X-RAY DIFFRACTION (3.3 Å)