8WIU
Bromodomain and Extra-terminal Domain (BET) BRD4
Summary for 8WIU
Entry DOI | 10.2210/pdb8wiu/pdb |
Descriptor | Isoform C of Bromodomain-containing protein 4, 7-[5-[1-(cyclopropylmethyl)-3,5-dimethyl-pyrazol-4-yl]pyridin-3-yl]-1~{H}-imidazo[4,5-b]pyridine (3 entities in total) |
Functional Keywords | binds acetylated lysine residues, dna binding protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 15084.46 |
Authors | |
Primary citation | Chen, X.,Wu, T.,Du, Z.,Kang, W.,Xu, R.,Meng, F.,Liu, C.,Chen, Y.,Bao, Q.,Shen, J.,You, Q.,Cao, D.,Jiang, Z.,Guo, X. Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis. Eur.J.Med.Chem., 265:116080-116080, 2023 Cited by PubMed: 38142510DOI: 10.1016/j.ejmech.2023.116080 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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