8WIU

Bromodomain and Extra-terminal Domain (BET) BRD4

8WIU の概要

• エントリーDOI: 10.2210/pdb8wiu/pdb
• 分子名称: Isoform C of Bromodomain-containing protein 4, 7-[5-[1-(cyclopropylmethyl)-3,5-dimethyl-pyrazol-4-yl]pyridin-3-yl]-1~{H}-imidazo[4,5-b]pyridine (3 entities in total)
• 機能のキーワード: binds acetylated lysine residues, dna binding protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15084.46

構造登録者

Cao, D.,Zhiyan, D.,Xiong, B. (登録日: 2023-09-25, 公開日: 2024-01-03)

• 主引用文献: Chen, X.,Wu, T.,Du, Z.,Kang, W.,Xu, R.,Meng, F.,Liu, C.,Chen, Y.,Bao, Q.,Shen, J.,You, Q.,Cao, D.,Jiang, Z.,Guo, X.; Discovery of a brain-permeable bromodomain and extra terminal domain (BET) inhibitor with selectivity for BD1 for the treatment of multiple sclerosis.; Eur.J.Med.Chem., 265:116080-116080, 2023; PubMed: 38142510; DOI: 10.1016/j.ejmech.2023.116080

実験手法

X-RAY DIFFRACTION (1.4 Å)