8WGU
Crystal structure of V30M-TTR in complex with compound 20
Summary for 8WGU
Entry DOI | 10.2210/pdb8wgu/pdb |
Descriptor | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-[2-ethyl-4,7-bis(fluoranyl)-1-benzofuran-3-yl]methanone (3 entities in total) |
Functional Keywords | transthyretin, amyloidosis, inhibitor, benziodarone derivative, transport protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 35793.29 |
Authors | Yokoyama, T. (deposition date: 2023-09-22, release date: 2024-05-15, Last modification date: 2024-05-29) |
Primary citation | Mizuguchi, M.,Nakagawa, Y.,Yokoyama, T.,Okada, T.,Fujii, K.,Takahashi, K.,Luan, N.N.T.,Nabeshima, Y.,Kanamitsu, K.,Nakagawa, S.,Yamakawa, S.,Ueda, M.,Ando, Y.,Toyooka, N. Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma. J.Med.Chem., 67:6987-7005, 2024 Cited by PubMed: 38670538DOI: 10.1021/acs.jmedchem.3c02286 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.508 Å) |
Structure validation
Download full validation report