8WG7
Cryo-EM structures of peptide free and Gs-coupled GLP-1R
Summary for 8WG7
Entry DOI | 10.2210/pdb8wg7/pdb |
EMDB information | 37504 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total) |
Functional Keywords | g protein-coupled receptor, ligand recognition, receptor activation, unimolecular agonist, membrane protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 5 |
Total formula weight | 158517.81 |
Authors | Cong, Z.T.,Zhao, F.H.,Li, Y.,Luo, G.,Zhou, Q.T.,Yang, D.H.,Wang, M.W. (deposition date: 2023-09-20, release date: 2024-03-06) |
Primary citation | Cong, Z.,Zhao, F.,Li, Y.,Luo, G.,Mai, Y.,Chen, X.,Chen, Y.,Lin, S.,Cai, X.,Zhou, Q.,Yang, D.,Wang, M.W. Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10:18-18, 2024 Cited by PubMed: 38346960DOI: 10.1038/s41421-024-00649-0 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.54 Å) |
Structure validation
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