8WD4

EGFR(L858R/T790/C797S) in complex with compound 5j

8WD4 の概要

• エントリーDOI: 10.2210/pdb8wd4/pdb
• 分子名称: Epidermal growth factor receptor, ~{N}-[3,3-bis(fluoranyl)propyl]-4-[[(2~{S})-butan-2-yl]amino]-6-[[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]amino]pyridine-3-carboxamide, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: egfr, c797s, drug discovery, oncoprotein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37976.33

構造登録者

Nishikawa, Y. (登録日: 2023-09-14, 公開日: 2023-12-20, 最終更新日: 2024-01-03)

• 主引用文献: Kageji, H.,Momose, T.,Nagamoto, Y.,Togashi, N.,Yasumatsu, I.,Nishikawa, Y.,Kihara, K.,Hiramoto, K.,Minami, M.,Kasanuki, N.,Isoyama, T.,Naito, H.; Synthesis, activity, and their relationships of 2,4-diaminonicotinamide derivatives as EGFR inhibitors targeting C797S mutation.; Bioorg.Med.Chem.Lett., 98:129575-129575, 2023; PubMed: 38065292; DOI: 10.1016/j.bmcl.2023.129575

実験手法

X-RAY DIFFRACTION (2.55 Å)