8WCB

Cryo-EM structure of the CHA-bound mTAAR1-Gq complex

Summary for 8WCB

Entry DOI	10.2210/pdb8wcb/pdb
EMDB information	37437
Descriptor	Engineered G-alpha-q subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Trace amine-associated receptor 1, ... (6 entities in total)
Functional Keywords	cha, mtaar1, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	155604.83
Authors	Rong, N.K.,Guo, L.L.,Zhang, M.H.,Li, Q.,Yang, F.,Sun, J.P. (deposition date: 2023-09-11, release date: 2023-12-27)
Primary citation	Shang, P.,Rong, N.,Jiang, J.J.,Cheng, J.,Zhang, M.H.,Kang, D.,Qi, L.,Guo, L.,Yang, G.M.,Liu, Q.,Zhou, Z.,Li, X.B.,Zhu, K.K.,Meng, Q.B.,Han, X.,Yan, W.,Kong, Y.,Yang, L.,Wang, X.,Lei, D.,Feng, X.,Liu, X.,Yu, X.,Wang, Y.,Li, Q.,Shao, Z.H.,Yang, F.,Sun, J.P. Structural and signaling mechanisms of TAAR1 enabled preferential agonist design. Cell, 186:5347-5362.e24, 2023 Cited by PubMed: 37963465 DOI: 10.1016/j.cell.2023.10.014 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.1 Å)

Structure validation