8WBZ

Cryo-EM structure of ACE2-B0AT1 complex with JX225

Summary for 8WBZ

• Entry DOI: 10.2210/pdb8wbz/pdb
• EMDB information: 37428
• Descriptor: Sodium-dependent neutral amino acid transporter B(0)AT1, Angiotensin-converting enzyme 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: transporter, complex, inhibitors, protein transport, protein transport-hydrolase complex, protein transport/hydrolase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 342910.68

Authors

Yan, R.,Hu, Z.,Dai, L. (deposition date: 2023-09-10, release date: 2024-09-11)

• Primary citation: Xu, J.,Hu, Z.,Dai, L.,Yadav, A.,Jiang, Y.,Broer, A.,Gardiner, M.G.,McLeod, M.,Yan, R.,Broer, S.; Molecular basis of inhibition of the amino acid transporter B 0 AT1 (SLC6A19).; Nat Commun, 15:7224-7224, 2024; PubMed: 39174516; DOI: 10.1038/s41467-024-51748-1

Experimental method

ELECTRON MICROSCOPY (3.2 Å)