8W9I

Crystal structure of bacterial prolyl-tRNA synthetase in complex with inhibitor PAA-5

Summary for 8W9I

• Entry DOI: 10.2210/pdb8w9i/pdb
• Descriptor: Proline--tRNA ligase, (2~{S})-~{N}-[3-(4-azanylquinazolin-7-yl)phenyl]sulfonylpyrrolidine-2-carboxamide, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: inhibitor, ligase
• Biological source: Pseudomonas aeruginosa
• Total number of polymer chains: 2
• Total formula weight: 129630.04

Authors

Luo, Z.,Zhou, H. (deposition date: 2023-09-05, release date: 2024-09-11)

• Primary citation: Luo, Z.,Zhou, H.; Structure-Guided Fluorine Scanning Accelerates the Discovery of Potent and Selective Inhibitors Against Bacterial Prolyl-tRNA Synthetase; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)