8W7D
Crystal structure of EcPPAT-FR901483 complex
Summary for 8W7D
Entry DOI | 10.2210/pdb8w7d/pdb |
Descriptor | Amidophosphoribosyltransferase, [(1S,3S,6S,7S,8R,9S)-6-[(4-methoxyphenyl)methyl]-3-(methylamino)-7-oxidanyl-5-azatricyclo[6.3.1.0^1,5]dodecan-9-yl] dihydrogen phosphate (2 entities in total) |
Functional Keywords | ppat, fr901483, immunosuppressant, self-resistance enzyme, molecular targeted drug, transferase |
Biological source | Escherichia coli K-12 |
Total number of polymer chains | 4 |
Total formula weight | 233058.93 |
Authors | Hara, K.,Hashimoto, H.,Nakahara, M.,Sato, M.,Watanabe, K. (deposition date: 2023-08-30, release date: 2023-12-13, Last modification date: 2023-12-27) |
Primary citation | Sato, M.,Sakano, S.,Nakahara, M.,Tamura, Y.,Hara, K.,Hashimoto, H.,Tang, Y.,Watanabe, K. Uncommon Arrangement of Self-resistance Allows Biosynthesis of de novo Purine Biosynthesis Inhibitor that Acts as an Immunosuppressor. J.Am.Chem.Soc., 145:26883-26889, 2023 Cited by PubMed: 38051581DOI: 10.1021/jacs.3c09600 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.81 Å) |
Structure validation
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