8W5C

Crystal structure of FGFR4 kinase domain in complex with 8K

Summary for 8W5C

Entry DOI	10.2210/pdb8w5c/pdb
Descriptor	Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide (3 entities in total)
Functional Keywords	transferase-inhibitor complex, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	68383.00
Authors	Zhang, Z.M.,Huang, H.S. (deposition date: 2023-08-26, release date: 2024-07-31)
Primary citation	Yang, F.,Lin, Q.,Song, X.,Huang, H.,Chen, X.,Tan, J.,Li, Y.,Zhou, Y.,Tu, Z.,Du, H.,Zhang, Z.M.,Ortega, R.,Lin, X.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X. Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67:2667-2689, 2024 Cited by PubMed: 38348819 DOI: 10.1021/acs.jmedchem.3c01810 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation