8W5C

Crystal structure of FGFR4 kinase domain in complex with 8K

8W5C の概要

• エントリーDOI: 10.2210/pdb8w5c/pdb
• 分子名称: Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: transferase-inhibitor complex, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68383.00

構造登録者

Zhang, Z.M.,Huang, H.S. (登録日: 2023-08-26, 公開日: 2024-07-31)

• 主引用文献: Yang, F.,Lin, Q.,Song, X.,Huang, H.,Chen, X.,Tan, J.,Li, Y.,Zhou, Y.,Tu, Z.,Du, H.,Zhang, Z.M.,Ortega, R.,Lin, X.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X.; Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.; J.Med.Chem., 67:2667-2689, 2024; PubMed: 38348819; DOI: 10.1021/acs.jmedchem.3c01810

実験手法

X-RAY DIFFRACTION (2.3 Å)