8W4V
Crystal structure of human HSP90 in complex with compound 4
Summary for 8W4V
Entry DOI | 10.2210/pdb8w4v/pdb |
Descriptor | Heat shock protein HSP 90-alpha, MAGNESIUM ION, 4-[2-[(dimethylamino)methyl]phenyl]sulfanylbenzene-1,3-diol, ... (4 entities in total) |
Functional Keywords | hsp90, atpase, ntd, complex, inhibitor, chaperone |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 27637.23 |
Authors | Xu, C.,Zhang, X.L.,Bai, F. (deposition date: 2023-08-25, release date: 2024-04-17, Last modification date: 2024-05-08) |
Primary citation | Xu, C.,Zhang, X.,Zhao, L.,Verkhivker, G.M.,Bai, F. Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies. Jacs Au, 4:1632-1645, 2024 Cited by PubMed: 38665669DOI: 10.1021/jacsau.4c00123 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.81 Å) |
Structure validation
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