8W4V

Crystal structure of human HSP90 in complex with compound 4

8W4V の概要

• エントリーDOI: 10.2210/pdb8w4v/pdb
• 分子名称: Heat shock protein HSP 90-alpha, MAGNESIUM ION, 4-[2-[(dimethylamino)methyl]phenyl]sulfanylbenzene-1,3-diol, ... (4 entities in total)
• 機能のキーワード: hsp90, atpase, ntd, complex, inhibitor, chaperone
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27637.23

構造登録者

Xu, C.,Zhang, X.L.,Bai, F. (登録日: 2023-08-25, 公開日: 2024-04-17, 最終更新日: 2024-05-08)

• 主引用文献: Xu, C.,Zhang, X.,Zhao, L.,Verkhivker, G.M.,Bai, F.; Accurate Characterization of Binding Kinetics and Allosteric Mechanisms for the HSP90 Chaperone Inhibitors Using AI-Augmented Integrative Biophysical Studies.; Jacs Au, 4:1632-1645, 2024; PubMed: 38665669; DOI: 10.1021/jacsau.4c00123

実験手法

X-RAY DIFFRACTION (1.81 Å)