8W4S
Crystal structure of PDE5A in complex with CVT-313
Summary for 8W4S
Entry DOI | 10.2210/pdb8w4s/pdb |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, MAGNESIUM ION, ZINC ION, ... (5 entities in total) |
Functional Keywords | pde5a, inhibitor, complex structure, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40581.28 |
Authors | |
Primary citation | Liu, J.,Zhang, X.,Chen, G.,Shao, Q.,Zou, Y.,Li, Z.,Su, H.,Li, M.,Xu, Y. Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors. Eur.J.Med.Chem., 262:115893-115893, 2023 Cited by PubMed: 37918035DOI: 10.1016/j.ejmech.2023.115893 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.848 Å) |
Structure validation
Download full validation report