8W10

Plasmodium vivax PMX-MK7602 inhibitor complex

8W10 の概要

• エントリーDOI: 10.2210/pdb8w10/pdb
• 分子名称: Aspartyl protease, putative, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (7 entities in total)
• 機能のキーワード: plasmepsinix, plasmepsinx, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Plasmodium vivax Sal-1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 87318.89

構造登録者

Hodder, A.N.,Scally, S.W.,Cowman, A.F. (登録日: 2024-02-14, 公開日: 2025-02-26, 最終更新日: 2026-03-11)

主引用文献

Favuzza, P.,Palandri, J.,de Lera Ruiz, M.,Bailey, W.,Boyce, C.W.,Danziger, A.,Fawaz, M.V.,Kelly, M.,Murgolo, N.,Robbins, J.A.,Vavrek, M.,Zhao, L.,Lei, Z.,Guo, Z.,Reaksudsan, K.,Steel, R.W.J.,Hodder, A.N.,Ngo, A.,Dziekan, J.M.,Thompson, J.K.,Triglia, T.,Birkinshaw, R.W.,Penington, J.S.,Scally, S.W.,Dans, M.G.,Coyle, R.,Sevilleno, N.,Orban, A.,Feufack-Donfack, L.B.,Popovici, J.,Lee, M.C.S.,Papenfuss, A.,Lowes, K.N.,Sleebs, B.E.,McCarthy, J.S.,McCauley, J.A.,Boddey, J.A.,Olsen, D.B.,Cowman, A.F.
MK-7602: a potent multi-stage dual-targeting antimalarial.
Ebiomedicine, 123:106061-106061, 2026

PubMed Abstract: The global burden of malaria remains substantial, and increasing parasite resistance to current antimalarials necessitates the development of drugs with unique mechanisms of action. This study aimed to develop and characterise a new antimalarial compound targeting Plasmodium aspartic proteases.

PubMed: 41353980
DOI: 10.1016/j.ebiom.2025.106061

実験手法

X-RAY DIFFRACTION (2.95 Å)