8W0X

Crystal structure of broadly neutralizing antibody hcab40 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain

8W0X の概要

• エントリーDOI: 10.2210/pdb8w0x/pdb
• 分子名称: Envelope glycoprotein E2, hcab40 Fab Heavy Chain, hcab40 Fab Light Chain, ... (9 entities in total)
• 機能のキーワード: hcv glycoprotein, broadly neutralizing antibodies, immune system, immune system-viral protein complex, immune system/viral protein
• 由来する生物種: Hepacivirus hominis; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 83721.46

構造登録者

Flyak, A.I.,Wilcox, X.E. (登録日: 2024-02-14, 公開日: 2024-03-27, 最終更新日: 2024-04-17)

• 主引用文献: Ogega, C.O.,Skinner, N.E.,Schoenle, M.V.,Wilcox, X.E.,Frumento, N.,Wright, D.A.,Paul, H.T.,Sinnis-Bourozikas, A.,Clark, K.E.,Figueroa, A.,Bjorkman, P.J.,Ray, S.C.,Flyak, A.I.,Bailey, J.R.; Convergent evolution and targeting of diverse E2 epitopes by human broadly neutralizing antibodies are associated with HCV clearance.; Immunity, 57:890-903.e6, 2024; PubMed: 38518779; DOI: 10.1016/j.immuni.2024.03.001

実験手法

X-RAY DIFFRACTION (3.12 Å)