8VZK

Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase CfhHACS from Chloroflexi bacterium in the Complex with THDP and ADP

Summary for 8VZK

• Entry DOI: 10.2210/pdb8vzk/pdb
• Descriptor: Oxalyl-CoA decarboxylase, THIAMINE DIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: 2-hydroxyacyl-coa lyase/synthase, oxalyly-coa decarboxylase, acyloin condensation, structural biology center, eberlight, lyase
• Biological source: Chloroflexi bacterium HGW-Chloroflexi-9
• Total number of polymer chains: 2
• Total formula weight: 122575.22

Authors

Kim, Y.,Gade, P.,Mayfield, A.,Endres, M.,Lee, S.,Yoshikuni, Y.,Gonzalez, R.,Michalska, K.,Joachimiak, A. (deposition date: 2024-02-11, release date: 2024-10-02)

• Primary citation: Kim, Y.,Lee, S.H.,Gade, P.,Nattermann, M.,Maltseva, N.,Endres, M.,Chen, J.,Wichmann, P.,Hu, Y.,Marchal, D.G.,Yoshikuni, Y.,Erb, T.J.,Gonzalez, R.,Michalska, K.,Joachimiak, A.; Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.; Commun Chem, 7:160-160, 2024; PubMed: 39034323; DOI: 10.1038/s42004-024-01242-y

Experimental method

X-RAY DIFFRACTION (2.65 Å)