8VZF

Crystal Structure of 2-Hydroxyacyl-CoA Lyase/Synthase ApbHACS from Alphaproteobacteria bacterium in the Complex with THDP, Coenzyme A, and ADP

8VZF の概要

• エントリーDOI: 10.2210/pdb8vzf/pdb
• 分子名称: 2-Hydroxyacyl-CoA Lyase/Synthase, S-{(9R,13S,15R)-17-[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]-9,13,15-TRIHYDROXY-10,10-DIMETHYL-13,15-DIOXIDO-4,8-DIOXO-12,14,16-TRIOXA-3,7-DIAZA-13,15-DIPHOSPHAHEPTADEC-1-YL} THIOFORMATE, THIAMINE DIPHOSPHATE, ... (10 entities in total)
• 機能のキーワード: 2-hydroxyacyl-coa lyase/synthase, acyloin condensation, oxalyl-coa decarboxylase, sbc, eberlight, lyase
• 由来する生物種: Alphaproteobacteria bacterium
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 246569.13

構造登録者

Gade, P.,Kim, Y.,Endres, M.,Lee, S.,Yoshikuni, Y.,Gonzalez, R.,Michalska, K.,Joachimiak, A. (登録日: 2024-02-11, 公開日: 2024-10-02)

• 主引用文献: Kim, Y.,Lee, S.H.,Gade, P.,Nattermann, M.,Maltseva, N.,Endres, M.,Chen, J.,Wichmann, P.,Hu, Y.,Marchal, D.G.,Yoshikuni, Y.,Erb, T.J.,Gonzalez, R.,Michalska, K.,Joachimiak, A.; Revealing reaction intermediates in one-carbon elongation by thiamine diphosphate/CoA-dependent enzyme family.; Commun Chem, 7:160-160, 2024; PubMed: 39034323; DOI: 10.1038/s42004-024-01242-y

実験手法

X-RAY DIFFRACTION (2.36 Å)