8VTX

Crystal structure of the A2058-N6-dimethylated Thermus thermophilus 70S ribosome in complex with macrolone MCX-128, mRNA, aminoacylated A-site Phe-tRNAphe, aminoacylated P-site fMet-tRNAmet, and deacylated E-site tRNAphe at 2.40A resolution

これはPDB形式変換不可エントリーです。

8VTX の概要

• エントリーDOI: 10.2210/pdb8vtx/pdb
• 分子名称: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (64 entities in total)
• 機能のキーワード: macrolone; macrolide; fluoroquinolone; erythromycin; ciprofloxacin; antibiotic; 70s ribosome; x-ray structure; inhibition of translation; peptidyl transferase center; nascent peptide exit tunnel; multidrug; resistance; methylation; 23s rrna; a2058; erm, ribosome
• 由来する生物種: Escherichia coli; 詳細
• タンパク質・核酸の鎖数: 112
• 化学式量合計: 4571688.86

構造登録者

Aleksandrova, E.V.,Ma, C.-X.,Klepacki, D.,Alizadeh, F.,Vazquez-Laslop, N.,Liang, J.-H.,Polikanov, Y.S.,Mankin, A.S. (登録日: 2024-01-27, 公開日: 2024-08-07)

• 主引用文献: Aleksandrova, E.V.,Ma, C.X.,Klepacki, D.,Alizadeh, F.,Vazquez-Laslop, N.,Liang, J.H.,Polikanov, Y.S.,Mankin, A.S.; Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms.; Nat.Chem.Biol., 2024; PubMed: 39039256; DOI: 10.1038/s41589-024-01685-3

実験手法

X-RAY DIFFRACTION (2.4 Å)